Monday, 2 December 2013

Liver diseases in pregnancy - Liver diseases induced by pregnancy - part 8

Second and third trimesters :
HELLP Syndrome :
Continued. .
Therapy and outcome:
The maternal morbidity rate has been reported to be as high as 24%, but it ranges between 1% to 4% in optimal medical environments.
Investigators found 16% maternal death rate attributed to hepatic complications.
The neonatal mortality rate associated with HELLP syndrome (10%–20%) has been attributed to placenta ischemia leading to abruption, extreme prematurity, and intrauterine asphyxia.
Factors associated with perinatal survival in preterm pregnancies with HELLP syndrome include achievement of a birth weight of at least 600g, elapsed time of 48 hours after medical therapy with steroids for perinatal lung maturity and caesarian delivery.
Termination of pregnancy is the only therapy.
With few exceptions, patients with pregnancies of at least 34 weeks gestation and class I pregnant patients with HELLP syndrome require prompt delivery. 

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