Tuesday 3 December 2013

Preterm labor - Prevention

Prevention of preterm labor:
By reducing the background risk factors.
By screening symptomatic and asymptomatic women with the risk of preterm delivery.
Treating the women with threatened and established preterm labor.
Improving the nutrition, providing rest, increasing hydration.
Giving psychological support.
Have to screen for risk factors, monitor the uterine activity.
 Assessing the markers of preterm labour, eg. Fibronectin, ultrasonographic changes.
By detecting and treating infections.
In selected patients, we can go for cervical circlage, progestin therapy or tocolytics.

Antenatal care:
Prenatal visits to be increased. Home visits should include in prenatal visits.
Social and psychological support needed.
Nutritional counseling to be done.

 Nutritional intervention:
Women with low pre-pregnancy BMI and poor weight gain during pregnancy have a high risk for preterm labor.
Zinc, Mg and fish oil supplementation show promising results in decreasing preterm labor.
 Iron supplementation have not shown reduction in the incidence of preterm labor.
Calcium supplementation reduced preterm labour in women who were at high risk of developing hypertension during pregnancy.
 Vit-C supplementation found to increase the risk of preterm labor.

 Bed rest: There is no conclusive evidence that bed rest prevents preterm labor. Bed rest for 3 days or more may increase thrombo embolic complications.

Hydration and sedation: Hydration with 500ml of crystalloid over 30 min and 8 to 12 mg intramuscular morphine sulphate had outcomes similar to those with best rest.
 In some women contractions treated with 0.25mg subcutaneous terbutaline ceased quickly.

HUAM: Home uterine activity monitoring(HUAM) with a device which consists of a tocodynamometer worn as a belt, a data recorder and transmitter. Uterine activity is monitored for two to one hour periods in a day and analyzed for evidence of onset of preterm labor. But its utility failed to show better outcome in preventing preterm labor.

Anti microbials: Antimicrobial treatment of women with preterm labor for the sole purpose of preventing delivery is generally not recommended.
As primary outcomes of neonatal death, chronic lung disease and major cerebral abnormality are similar in both antimicrobial or placebo therapy groups.


Preterm labor-etiologicalfactors
Preterm labor-pathogenesis and diagnosis
Preterm labor-investigations
Preterm labor-prediction
Preterm labor-complications
Preterm labor -prevention
Preterm labor-bacterialvaginosis
Preterm labor-progesterone.html
Preterm labor-cervical circlage
Pretem labor-management
Preterm labor-tocolytics
Preterm labor-with premature rupture of membranes

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