Liver diseases in pregnancy - Liver diseases induced by pregnancy - part 6

Second and third trimesters :
HELLP Syndrome:
Continued. .
Laboratory investigations:
Risk factors for HELLP syndrome include the following:
LDH level > 1400 IU/L
AST level > 150 IU/L
ALT level > 100 IU/L
Platelet count < 50,000/mm3
Uric acid level > 7.8 mg/dL Creatinine level > 1.0
Creatine phosphokinase level > 200 IU/L

Liver function:
Patients usually are not jaundiced. Total bilirubin concentration rarely exceeds 1 to 2 mg.
HELLP syndrome rarely leads to subcapsular hemorrhage.
 Hepatic rupture often leads to death of the mother and fetus. Typically, these patients present with shock and hemoperitoneum. The condition also may manifest hepatic infarcts with associated fevers, high levels of aminotranferase (N5000 IU/L) and anemia.