Vaso dilators:
Eg.Hydralazine hydrochloride:
Acts directly on arterial smooth muscles to cause vasodilatation.
Dose 25 to 100mgs, 3to4 times/day. Maximum dose 300mgs/day.
Side effects: fluid retention, tachycardia, headache, neonatal lupus like syndrome with thrombocytopenia.
Alpha 1 blockers:
Eg.Prazosin:
Selective competitive antagonist of alpha 1 receptors.
Dilates both capasitance & resistance vessels.
Dose: 0.5mgs twise daily.
Side effects: chest pain, shortness of breath, loss of bladder control.
Diuretics:
Used in severe cases of preeclamsia or eclampsia ass with severe edema, acute pulm edema or renal failure.
Not recommended in presence of IUGR, doppler evidence of reduced uteroplacental perfusion.
Use of thiazide diuretics inc serum urate.
Side effects: hypercalcemia, hypomagnesia, hyponatremia.
Eg. Loop diuretic furosemide:
With rapid onset of action used in management of acute pulmonary edema.
Dose:40 to80 mgs.
ACE(Angiotensin convertage) inhibitors:
Contraindicated in pregnancy, particularly in 2nd & 3rd trimesters.
Exposure to captopril, enalapril & lisinopril result in IUGR, oligohydramnios, neonatal renal failure and even death.
They may be used in low doses in post partum period for severe postpartum HTN.
-Hypertension in pregnancy-classification
-Hypertension in pregnancy-gestational hypertension
-Preeclampsia
-Eclampsia, preeclamsia superimposed on chronic hypertension
-Chronic hypertension
-Hypertension in pregnancy-etiology and pathogenesis
-Pathology
-Mild hypertension in pregnancy-prevention and management
-Severe hypertension in pregnancy-management
-Severe preeclampsia in pregnancy-management
-Complications of hypertension
-Antihypertensive therapy- centrally acting drugs
-Antihypertensive therapy-beta blockers, calcium channel blockers
-Antihypertensive therapy-alpha blockers, vasodilator, diuretics, ACE inhibitors
-Acute severe hypertension - treatment
-Eclampsia - signs and symptoms
-Eclampsia - management
Eg.Hydralazine hydrochloride:
Acts directly on arterial smooth muscles to cause vasodilatation.
Dose 25 to 100mgs, 3to4 times/day. Maximum dose 300mgs/day.
Side effects: fluid retention, tachycardia, headache, neonatal lupus like syndrome with thrombocytopenia.
Alpha 1 blockers:
Eg.Prazosin:
Selective competitive antagonist of alpha 1 receptors.
Dilates both capasitance & resistance vessels.
Dose: 0.5mgs twise daily.
Side effects: chest pain, shortness of breath, loss of bladder control.
Diuretics:
Used in severe cases of preeclamsia or eclampsia ass with severe edema, acute pulm edema or renal failure.
Not recommended in presence of IUGR, doppler evidence of reduced uteroplacental perfusion.
Use of thiazide diuretics inc serum urate.
Side effects: hypercalcemia, hypomagnesia, hyponatremia.
Eg. Loop diuretic furosemide:
With rapid onset of action used in management of acute pulmonary edema.
Dose:40 to80 mgs.
ACE(Angiotensin convertage) inhibitors:
Contraindicated in pregnancy, particularly in 2nd & 3rd trimesters.
Exposure to captopril, enalapril & lisinopril result in IUGR, oligohydramnios, neonatal renal failure and even death.
They may be used in low doses in post partum period for severe postpartum HTN.
-Hypertension in pregnancy-classification
-Hypertension in pregnancy-gestational hypertension
-Preeclampsia
-Eclampsia, preeclamsia superimposed on chronic hypertension
-Chronic hypertension
-Hypertension in pregnancy-etiology and pathogenesis
-Pathology
-Mild hypertension in pregnancy-prevention and management
-Severe hypertension in pregnancy-management
-Severe preeclampsia in pregnancy-management
-Complications of hypertension
-Antihypertensive therapy- centrally acting drugs
-Antihypertensive therapy-beta blockers, calcium channel blockers
-Antihypertensive therapy-alpha blockers, vasodilator, diuretics, ACE inhibitors
-Acute severe hypertension - treatment
-Eclampsia - signs and symptoms
-Eclampsia - management
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