Vulval leukoplakia – part 3

Prevention:

-Pertinacious diet containing vitamins, minerals etc. should  include milk, eggs etc.

-Treating provoking factors like diabetes, endocrine diseases etc.

-Treating EB virus, candidial infections etc.

-Maintaining vulval local health like reducing the moisture, friction, heat production etc.

Treatment:

-With appropriate and early intervention around 96 to 97% cases can be prevented from becoming worse.

-Local treatment – to keep the vulva clean and dry.

-Using mild soaps and avoiding soap over scrub etc.

-For itching local corticosteroids can be used.

-For keratosis proliferative lesions topical 0.025% to 0.05% Vitamin-A acid ointment or 2.5% fluorouracil ointment can be used.

(Fluorouracil helps in blocking the conversion of uracil into thymidine. Thereby it inhibits DNA synthesis, which prevents tumor cell proliferation and differentiation. It can be used in precancerous skin lesions and also in malignant skin lesions.)

 -Leukoplakia with mild dysplasia can be treated with this combination therapy and long term follow-up.

-In case of leukoplakia lesions with atypical cellular features with possibility of development of carcinoma in situ needs surgery.