Saturday, 30 November 2013

Ovarian tumors - management of malignant tumors - part 6

4.Radiotherapy:
Abdominal radiotherapy gives salvage treatment with high morbidity. Dysgerminomas
 are very sensitive to radiation, but lead to infertility.

5.Immunotherapy:
Cytokines like interferon-a, r and interleukin-2 are used.
Monoclonal antibodies are directed towards ovarian cancer associated antigens.
Others are CA125 – ovarex, HMFG – antimucin MonAb, Herceptin – breast ca.

6.Hormonal therapy:
Progestational agents : Used in the treatment of recurrent well differentiated endometrioid carcinomas.
Tamoxifen : For well differentiated ca.
Leuprolide acetate: Is a gonadotropin agonist.
Aromatase inhibitors : letrozole, anastrazole, exemestane for breast ca and relapsed ovarian ca. 

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