Sunday, 1 December 2013

Liver diseases in pregnancy - Liver diseases coincidental with but not induced by pregnancy- part 4

Acute viral hepatitis and other viral infections :
Hepatitis E:

 Shares the route of transmission, risk factors, and chronicity rate with HAV.
During pregnancy, HEV can cause fulminant hepatitis indistinguishable from AFLP.
There is a significant mortality rate of 16% in pregnant women with acute HEV infection.
Transmission occurs intrapartum and peripartum through close contact of mother and neonate. Evidence suggests significant vertical transmission among HEV-RNA positive mothers of up to 50%.
 Among women with symptomatic infection the rate of transmission is up to 100%, with significant perinatal morbidity and mortality.




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