Liver diseases in pregnancy - Liver diseases induced by pregnancy - part 12

Second and third trimesters :
Acute Fatty Liver of Pregnancy :
Continued. .
Laboratory tests:
Biochemical changes:
Bilirubin (total) - slight elevated or normal
AST/ALT- normal to 1000 U
GGTP - slightly elevated Prothrombin time - elevated Fibrinogen - decreased
Uric acid - elevated
Ammonia - elevated
Glucose - decreased
Leukocytes - elevated
Platelets - slight elevated or normal Imaging may be useful, fat in the liver has been demonstrated in AFLP with ultrasonography and CT scanning.
Liver biopsy is not indicated for diagnosis.

Complications:
Cerebral edema
Renal failure (60%)
Hypoglycemia (53%)
Infections (45%)
Gastrointestinal hemorrhage (33%), Coagulopathy (30%)
Fetal death
Severe postpartum hemorrhage etc.