Thursday 28 November 2013

Risk factors of having child with autism

Children with autism will have abnormalities in brain development and behavior.
This can be seen before the child attains three years, it will have steady course without remission.
These children will present with symptoms like :
-Impairment in social interaction and communication
-Restricted interests
-Streriotyped behavior etc.

The theory of causation of autism is incomplete.
The possibility of autism depends on many risk factors like :
- Maternal diabetes.
-Increased paternal and maternal age.
-Genetic factors. But it is not established which gene is responsible to cause autism.
-Autoimmune diseases to mother.
-Exposure to teratogenic agents.
- Intrauterine infections.
-Stress and strain pre conceptionally can lead to autism by gene-environment interaction.
-Hypothyroidism in mother etc.
-High levels of testosterone in amniotic fluid.
This can be diagnosed by amniocentesis.
- Nutritional deficiency, especially folic acid deficiency.
- Intake of drugs like antidepressants during pregnancy.


The possible steps that can be taken to avoid autism to some extent are :
- Maintaining strict normal blood sugar levels for at least 3 months before planning for pregnancy.
-Staring folic acid supplementation 2 to 3 months prior to pregnancy.
-Regular antenatal checkups and ultrasound examinations during pregnancy.
-Some studies recommend estimation of testosterone levels in the amniotic fluid by amniocentesis. But its role is somewhat doubtful.
-Avoiding the risk factors like nutritional deficiency, teratogens etc.



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