Wednesday 27 February 2013

TORCH group of infections - Rubella



Rubella infection also called as German measles is caused by Rubella virus.
If this infection occurs in non-pregnant women, usually the severity will be minimal.
If infection occurs in pregnancy it will present with more severity and it can cause abortion, severe congenital malformations etc.

Features of maternal infection:
-Usually viremia precedes 1 week to clinical disease.
-Generally 25% of infected women will be asymptomatic.
-Clinical features: lymphadenopathy, fever, malaise, arthralgia etc.
 Maculopapular rash can occur. It starts on the face and spreads to the trunk and     extremities.


Effects on fetus:
With progression of pregnancy the possibility of congenital malformations will decrease.
Usually most sequelae are seen before 20 weeks.

Congenital rubella syndrome:
 It can present with one or more of below findings:
-Eye lesions like cataracts, glaucoma, microphthalmia and other abnormalities.
-Heart diseases like patent ductus arteriosus, septal defects and pulmonary artery stenosis.
-Sensorineural deafness.
-Central nervous system defects including  meningoencephaliis.
-Fetal growth restriction.
-Thrombocytopenia, anemia
-Hepaitis, hepatosplenomegaly, jaundice
-Chronic diffuse interstitial pneumonitis.
-Osseous changes.
-Chromosomal abnormalities.

Infants born with congenital rubella syndrome may shed the virus, It can continue for months, other infants and susceptible adults who came in contact to these infants can get affected with this.

Extended rubella syndrome:
-Progressive panencephalitis.
-Type 1 diabetes mellitus – it may develop clinically in second and third decades of life.
-One third of asymptomatic infants at birth may manifest such developmental injury later in life.
-Other later sequalae are : thyroid disease, ocular damage, mental retardation etc.


Vaccination:
For complete eradication of the disease vaccination is recommended.
-Health education to all.
-Vaccination of susceptible women.
-Vaccination of unimmunized women immediately after child birth and abortion.
-Vaccination to unmarried teenage girls.
-Susceptible hospital personnel who might be exposed to patients with rubella or might have contact with pregnant women.
As vaccine contains attenuated live virus vaccination should be avoided shortly before or during pregnancy. But there is no evidence that the vaccine induced malformations.



Treatment:
No effective therapy for maternal infections. Symptomatic therapy with anti-viral drugs can be given.
Acyclovir 200mg, five times a day for five days can be given.




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